MARIA CARMINA CASTIELLO

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​Dr. Maria Carmina Castiello is Staff Scientist at San Raffaele Telethon institute for Gene therapy (SR-Tiget) and Researcher at the CNR-Institute of Genetic and Biomedical Research (IRGB) in Milan, Italy. She graduated at Università degli Studi di Napoli Federico II with a Master of Science Degree in Medical Biotechnology in 2007, where she studied the role of anti-apoptotic and growth factors in cardiovascular diseases. She then moved to Milan reaching the Unit of Pathogenesis and Treatment of Immune and Bone Diseases at San Raffaele Telethon institute for Gene therapy (SR-Tiget). In 2011, she was a visiting fellow at the Department of Molecular Immunology at the Erasmus Medical Center in Rotterdam (The Netherlands). She earned her PhD from Vita-Salute San Raffaele University (Milan) in 2013 defining B lymphocyte and platelet defects in Wiskott-Aldrich Syndrome primary immunodeficiency and evaluating their correction in patients treated by lentiviral vector mediated gene therapy. She performed her postdoctoral studies at SR-Tiget on mechanisms underlying autoimmunity in immunodeficiency and innovative therapeutic approaches to correct immunodeficiencies. In 2019, she received a permanent position as Researcher at the CNR-Institute of Genetic and Biomedical Research (IRGB) in Milan. She is now coordinating projects on translational medicine including the development of genome editing approach and novel non-genotoxic conditioning regimens to improve the safety and outcome of hematopoietic stem cell transplant in immunodeficiencies.